图书简介
’e of the reasons for all the F ASEB Societies to meet yearly is the possibility O to interrelate recent progress in diverse areas of research. The F ASEB Conferences have been organized to promote such interdisciplinary approaches. They center around a basic theme with the aim of discussing active research, in cluding widely divergent approaches, towards a better understanding of a general biological phenomenon. Because of the mounting interest in the subject of aging and development, this has been chosen as the theme for this year’s symposia. We have necessarily been limited in the number of topics that could be covered. In our choice we have attempted to’ select those facets of the main subject which at this time are gen erating active research interest among our membership. We have included invited speakers from abroad, such as Drs. Goldstein, Liew and Miller from Canada and Drs. Wolpert, Holliday and Williamson from England. I am sorry to say that the two speakers that we had invited from Russia, Dr. Frolkis, and from Czechoslovakia, Dr. Sterzl, were unable to attend.
Session I Theoretical Concepts of Developmental and Age Changes.- Implications of aging research for society.- Current theories of biological aging.- Towards a theory of development.- Session II Gene Regulation in Differentiation and Development.- Introductory remarks.- Surface reorganization as an initial inductive event in the differentiation of prothymocytes to thymocytes.- Germ line basis for antibody diversity.- Sequential expression of germ line genes in development of immunoglobulin class diversity.- Normal and altered phenotypic expression of immunoglobulin genes.- Expression of specific clones during B cell development.- Session III Finite Versus Infinite Proliferative and Functional Capacities of Cells.- Growth and death of diploid and transformed human fibroblasts.- Pathological implications of cell aging in vitro.- Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation.- Restricted replicative life-span of diabetic fibroblasts in vitro: its relation to microangiopathy.- Hayflick’s hypothesis: an approach to in vivo testing.- Contributions of cytoplasmic factors to in vitro cellular senescence.- Session IV Aging of Homeostatic Control Systems.- Introductory remarks.- Age-related changes in thermoregulatory capacity of tryptophan-deficient rats.- Zinc deficiency and brain development in the rat.- Neuronal—glial interactions during development and aging.- Pituitary inhibitor of thyroxine.- Bioenergetic functions of sleep and activity rhythms and their possible relevance to aging.- Changes in monoamine oxidase and monoamines with human development and aging.- Procaine HCl (Gerovital H3): a weak, reversible, fully competitive inhibitor of monoamine oxidase.- Discussion of papers on aging of homeostatic control systems.- Session V Development and Aging in Organ Systems.- Ontogeny of mouse T-lymphocyte function.- Differentiation of thymus cells.- Development of B lymphocytes.- Ontogeny of B-lymphocyte function with respect to the heterogeneity of antibody affinity.- Effects of aging on the differentiation and proliferation potentials of cells of the immune system.- Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice.- Panel discussion on T-cell heterogeneity.- Session VI Development and Aging at the Molecular Level.- Development and aging at the molecular level.- Hormonal regulation of hepatic P-enolpyruvate carboxykinase (GTP) during development.- Pre- and postnatal enzyme capacity for drug metabolite production.- Impaired hormonal regulation of enzyme activity during aging.- Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive responsiveness.- Covalent modification of nuclear proteins during aging.- Effects of aging on ionic movements of atrial muscle.- Enzymatic studies on the skeletal myosin A and actomyosin of aging rats.
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